Acquired Aplastic Anemia

Acquired aplastic anemia.

In aplastic anemia, hematopoiesis fails: Blood cell counts are extremely low, and the bone marrow appears empty. The pathophysiology of aplastic anemia is now believed to be immune-mediated, with active destruction of blood-forming cells by lymphocytes. The aberrant immune response may be triggered by environmental exposures, such as to chemicals and drugs or viral infections and, perhaps, endo...

Aplastic Anemia - Diagnos tics and Therapy of Acquired Aplastic Anemia

Aplastic Anemia: Acquired and Inherited

Acquired aplastic anemia is a clinical syndrome in which there is a deficiency of red cells, neutrophils, monocytes, and platelets in the blood, and fatty replacement of the marrow with a near absence of hematopoietic precursor cells. Reticulocytopenia, neutropenia, monocytopenia, and thrombocytopenia, when severe, are life-threatening because of the risk of infection and bleeding, complicated ...

How I treat acquired aplastic anemia.

Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive biologics and drugs, and supportive care. However, management of SAA patients remains challenging, both acutely in addressing the immediate consequences of pancytopenia and in the long term because of the disease's natural history...

How I treat acquired aplastic anemia

AcquiredSAAis regardedas the resultof an immune-mediateddestruction of hematopoietic cells, at least in a proportion of patients. The emergence of late clonal disorders in10%to20%ofpatients after immunosuppressive therapy (IST) raises the questions of whether some patients with SAA actually have a premalignant disease and whether IST is just postponing the inevitable. Support for this view has ...